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KMID : 0369820080380020105
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Jorunal of Korean Pharmaceutical Sciences
2008 Volume.38 No. 2 p.105 ~ p.110
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Preparation and Dissolution Characteristics of Sustained Release Granules Containing Indapamide
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Park Ji-Seon
Seo Hui
Kim Byung-Jin
Jeong Sang-Young
Shin Byung-Cheol
Yuk Sun-Hong
Hwang Sung-Joo
Cho Sun-Hang
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Abstract
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Indapamide (4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoyl-benz-amide) is an oral antihypertensive diuretic agent indicated for the treatment of hypertensive. The diuretic and natriuretic effects are mainly due to the structure of o-chlorobenzenesulfonamide. The objective of this study was to formulate sustained release indapamide granules and assess their formulation variables. Granules were prepared by fluid bed coating method and consist of drug layer and membrane layer. The granules were coated with HPC and ethyl cellulose along with plasticizer dibuthyl sebacate. The release of indapamide depended on the type of Eudragit such as RS and NE 30 D used in the formulation controlled release layer. These results obtained clearly suggest that the sustained release oral delivery system for indapamide could be designed with satisfying drug release profile approved.
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KEYWORD
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Indapamide, Sustained release, Eudragit, Fluid-bed coating
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